An FDA-approved clinical trial is being conducted to test whether a non-invasive technology safely and effectively reduces pain from bone metastases. This outpatient procedure destroys the pain-causing nerves in the bone surface surrounding the tumor to relieve pain.
This non-invasive technology is called Magnetic Resonance guided Focused Ultrasound (MRgFUS), and is being used on an ExAblate system.
MRI-guided FUS: history, present & future
Ferenc Jolesz, M.D.
Director, National Center for Image Guided Therapy
Professor of Radiology, Harvard Medical School
The application of acoustic energy for tumor treatment is not a new idea. More than a half century ago, focused ultrasound (FUS) was already considered viable as a ―surgical‖ technique for treating deeply embedded soft tissue tumors non-invasively. Despite this early recognition of its potential, FUS has not been widely accepted as a real alternative to invasive surgery. The reason is not the limitation of focused ultrasound technology but the inadequacy of image-guidance and the control of energy deposition. We strongly believe that the integration of FUS with Magnetic Resonance Imaging (MRI) represents a major step towards a non-invasive image-guided therapy substitute that can replace most of the existing tumor surgery methods. MRI guided Focused Ultrasound Surgery (MRgFUS) that has been developed during the last decade provides accurate targeting of focused sound waves that can be directed to destroy tumor tissue within MRI detected tumor margins. MRI not only provides tumor localization with high sensitivity but also monitors temperature distribution in /real time/, effectively generating ―temperature maps‖ of the targeted surgical field/ /during treatment. In turn, FUS delivers thermal energy at safe, therapeutically effective doses /without/ damaging collateral normal tissue. The integration of MRI and FUS creates an image-guided therapy delivery system with which /real time/, image-controlled, non-invasive soft tissue coagulation is feasible; and from which a wide range of clinical applications may ultimately benefit.
Although MRgFUS technology is still in its infancy, this revolutionary disruptive imaging technology has already been established as a viable, non-invasive treatment for uterine fibroids, breast carcinomas, certain brain malignancies, and for palliative treatment of bone tumors. With additional research, we will no doubt develop MRgFUS applications for CNS and vascular diseases, targeted drug delivery, gene therapy, and more. The integration of MRI and Focused Ultrasound Surgery (FUS) has resulted in/ real time/, image-controlled, closed loop-feedback based, non-invasive therapy delivery systems. Moreover, MRI has the ability to control tissue heating and the deposition of thermal dose. This feature significantly improves the safety and efficacy of FUS in the treatment of tumors. The major advantage of MRI-guidance over other imaging modalities is its ability to achieve accurate targeting while avoiding thermal injury of normal tissues. Over the next decade, MRgFUS will almost certainly replace several invasive open surgeries and will likely supplant minimally invasive approaches as the preferred treatment approach.
Hi! I've recently had a bunch of medical issues that no one seems to know the root cause of.Fatigue and sleep problems have really been effecting my life lately.Not sure if they are symptoms of something else or not.How did you go about getting your fatigue/sleep disorder diagnosed? Has anyone done an over night sleep study?Is there an other group I should check out on LJ?
A New Approach to Migraine Treatment
January 22, 2009
By Kulreet Chaudhary, M.D., Scripps Memorial Hospital La Jolla
According to an old saying, you are what you eat. Now, according to new research, your migraine headaches might be a result of what you eat, too.
In one sense, this is nothing new. Most migraine sufferers, as well as neurologists who manage migraines, know there is a connection between food and the onset of these extremely painful headaches. Many people who have migraines know that certain foods act as triggers; the most common culprits include chocolate, red wine, cheese, and other foods high in nitrates. Neurologists, in turn, will tell people to simply avoid these foods. However, until now we haven’t taken the next step of studying the greater relationship between digestion and migraine—a relationship that a study in the medical journal Headache
suggests is highly significant. ( Read more...Collapse )
Gulf War Research Panel Finds 1 In 4 Veterans Suffers From Illness Caused By Toxic ExposureScienceDaily (Nov. 17, 2008)
— At least one in four of the 697,000 U.S. veterans of the 1991 Gulf War suffer from Gulf War illness, a condition caused by exposure to toxic chemicals, including pesticides and a drug administered to protect troops against nerve gas, and no effective treatments have yet been found, a federal panel of scientific experts and veterans concludes in a landmark report released Monday.
The Congressionally-mandated Research Advisory Committee on Gulf War Veterans' Illnesses presented the report November 17 to Secretary of Veterans Affairs James Peake at VA headquarters in Washington.
"The extensive body of scientific research now available consistently indicates that Gulf War illness is real, that it is the result of neurotoxic exposures during Gulf War deployment, and that few veterans have recovered or substantially improved with time," the report says. ( Read more...Collapse )
UC San Diego Studies on Gulf War Veterans Continue
Leading Expert on Gulf War Illness
Seeking Participants: “At last, a treatment study!”
July 18, 2008
By Kim Edwards
In a follow up study to a breaking news story that found evidence linking illnesses in Persian Gulf War Veterans to exposure to certain chemicals, a group of researchers at UC San Diego School of Medicine is launching the next in a series of studies related to Gulf War Illnesses – this time seeking to help these veterans’ health.
Beatrice Golomb, M.D., Ph.D., associate professor, Division of General Internal Medicine, UC San Diego School of Medicine and attending physician, VA San Diego Healthcare System, is spearheading a Department of Defense-funded clinical trial, CoEnzyme Q10 for Gulf War Veterans, enrolling 40 veterans with Gulf War Illness in the San Diego area. ( Read more...Collapse )
Description: People who suffer from chronic fatigue syndrome (CFS) often endure months of persistent fatigue, muscle pain, and impaired memory and concentration. A new study reveals that abnormally low morning concentrations of the hormone cortisol may be correlated with more severe fatigue in CFS patients, especially in women.
Newswise — People who suffer from chronic fatigue syndrome (CFS) often endure months of persistent fatigue, muscle pain, and impaired memory and concentration. Understanding the physiological changes that accompany CFS, however, has been difficult, but a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism (JCEM)
reveals that abnormally low morning concentrations of the hormone cortisol may be correlated with more severe fatigue in CFS patients, especially in women. ( Read more...Collapse )
Pain Processing in the Brain Is Affected by a History of Abuse
By RADHA CHITALE
ABC News Medical Unit
April 4, 2008
About one in 50 infants in the United States experiences abuse or neglect in the first year of life. That's according to a government report published this week, which also details what might happen to them as adults.
"[These] children are at risk for poor health outcomes as adults," said Ileana Arias, director of the Center for Disease Control and Prevention's National Center for Injury Prevention and Control, which, along with the Administration for Children and Families, created the report. Though their health can be affected indirectly because of risky behavior patterns, such as drug use, Arias said that direct connections to the early abuse exist as well. ( Read more...Collapse )
Medscape Medical News 2008. © 2008 Medscape
February 6, 2008 — A new study indicates that chronic pain has a widespread impact on overall brain function, a finding that may offer a possible explanation for many of the common cognitive and behavioral comorbidities seen in such patients. ( Read more...Collapse )